The transformation of work structures in the knowledge-based economy has accelerated due to technological advancements, hybrid work arrangements, and policy reforms such as the National Education Policy (NEP) 2020. These developments have significantly influenced organizational approaches to work–life balance (WLB). The present study evaluates strategic transformations in work–life balance practices within knowledge-based sectors in the post-NEP 2020 era using secondary data sources. Reports from global organizations, policy documents, and scholarly publications were analyzed to understand emerging workplace practices and their implications for employees and organizations. Findings indicate that hybrid work models, digital skill development, and employee wellbeing initiatives are central strategies adopted by organizations to enhance productivity and employee satisfaction. The study highlights that NEP 2020 indirectly influences workforce preparedness by emphasizing multidisciplinary education, skill-based learning, and digital literacy, which shape future workplace expectations. Additionally, reports from global agencies emphasize the increasing importance of mental health support and flexible work policies in improving employee engagement. The research concludes that organizations in knowledge-driven sectors must adopt strategic HR policies that integrate flexible work arrangements, technological integration, and mental health support to sustain productivity and ensure employee well-being. The study contributes to the existing literature by synthesizing policy and industry perspectives to explain how modern work environments are evolving in response to educational reforms and technological transformation.