The field of Prognostics and Health Management is becoming ever more important in the modern maintenance era, with advanced techniques of automation and mechanisation becoming increasingly prevalent. Prognostic technology has promising abilities to forecast remaining useful life and likely future circumstances of complex systems. However, the evolution of data processing and its critical impact on remaining useful life predictions continually demand increasing development so as to meet higher performance levels. There is often a gap between the adequacy of prognostic pre-processing and the prediction methods. One way to reduce this gap would be to design an adaptive data processing method that can filter multidimensional condition monitoring data by incorporating useful information from multiple data sources.Due to the incomplete understanding on the multi-dimensional failure mechanisms and the collaboration between data sources, current prognostic methods lack the ability to deal effectively with complicated interdependency, multidimensional condition monitoring information and noisy data. Further conventional methods are unable to deal with these efficiently. The methodology proposed in this research handles these deficiencies by introducing a prognostic framework that allows the effective use of monitoring data from different resources to predict the lifetime of systems. The methodology presents a feed-forward neural network filtering approach for trajectory similarity based remaining useful life predictions. The extraction of health indicators is applied as a type of dynamic filtering, in which the time series having full operational conditions are used to train a neural network mapping between raw training inputs and a health indicator output. This trained network function is evaluated by repeating condition monitoring information from multiple data subsets. After the network filtering, the training trajectories are used as baselines to predict the future behaviours of test trajectories. The similarity between these data subsets compares the relationship between the historical performance deterioration of a system's prior operating period with a similar system's degradation behaviour.The proposed prognostic technique, together with dynamic data filtering and remaining useful estimation, holds the promise of increased prediction performance levels. The presented methodology was tested using the PHM08 data challenge provided by the Prognostics Centre of Excellence at NASA Ames Research Centre, and it achieved the overall leading score in the published literature.