Aims- The aims of this study was to compare the clinical efficacy of three different modes of mouth exercise in the management of Oral Submucous Fibrosis (OSMF). Methods- The study included a total of 45 subjects diagnosed with oral submucous fibrosis (OSMF), all of whom had no other systemic diseases. The participants were randomly divided into three groups, with 15 patients in each group. Group I performed balloon-blowing exercises, Group II followed an exercise regimen using ice-cream sticks, and Group III used a mouth opener device. The interincisal distance (IID) was measured using a digital Vernier caliper at the beginning of the study and after two months of intervention. Results: All three groups showed a statistically significant increase in mouth opening over 8 weeks, with Group 1 improving from 29.20 ± 3.73 mm to 31.40 ± 3.98 mm, Group 2 from 30.27 ± 3.01 mm to 34.33 ± 3.04 mm, and Group 3 from 29.33 ± 2.44 mm to 33.27 ± 2.37 mm, with the greatest percentage increase observed in Group 2 (13.60%), followed by Group 3 (13.57%) and Group 1 (7.60%). Conclusion: The management of OSMF patients should primarily be focused towards improving the MO and increasing flexibility of the oral mucosa to halt the possibility of malignant changes and thus mouth exercise physical therapy independently or in combination with other modalities may be useful to improve mouth opening (MO) in OSMF.