The dataset contains experimental data of the porcine brain regions corona radiata (CR), putamen (P) and thalamus (T) measured with large strain multimodal mechanical testing and magnetic resonance elastography. Large strain multimodal (LSMM): The testing protocol includes three cycles of compression and tension with 15% stretch and a strain rate of 0.01 s-1 (_CyclicCompressionTension.txt), compression relaxation with 15% stretch, a strain rate 0.025 s-1, and holding period 300 s (_RelaxCompressionTension.txt), and three cycles of torsional shear with a shear strain of 15% and a loading rate of 0.333 rad s-1 and three cycles of torsional shear with a shear strain of 30% and a loading rate of 0.1667 rad s-1 (_CyclicalTorsion.txt). The data has been filtered (moving average) and split into each loading mode. The samples were cylindrical and the height and diameter of each sample are given in the _Dimension.txt file. Magnetic resonance elastography (MRE): Storage and loss modulus for frequencies between 300 to 2100 Hz. Individual frequency points at 300Hz of the corona radiata suffered from an inefficient wave stimulation, leading to unphysical values for the storage and loss modulus; these data points were consequently excluded from the measurement.