The stomach is one of the main organs of the digestive system, responsible for temporary storage of food, its mechanical and chemical processing, chyme formation, and preparation of nutrients for further digestion. This article comprehensively covers the anatomical structure of the stomach (regions: cardia, fundus, body, antrum, and pylorus; wall layers, glandular epithelium, and specialized cells), its physiological features (gastric juice secretion, motility, hormonal and neural regulation), and its role in the digestive process. The article serves as a useful resource for medical students, professionals, and anyone interested in the physiology of the digestive system.