In addition to being at risk of fatal overdose, people who use drugs — especially those who inject substances — are at risk of experiencing soft tissue infections, endocarditis, and bloodborne infections such as HIV and hepatitis C virus (HCV). People who use drugs may have other chronic or acute health issues that need to be addressed; however, personal and structural barriers may prevent them from engaging with traditional health care settings. Syringe services programs (SSPs) deliver essential, evidence-based services to people who use drugs, including the distribution of safer drug use equipment and naloxone. SSPs are increasingly expanding to implement clinical services in response to their participants’ desires to access such support in one location and in a nondiscriminatory or stigmatizing way. Staff members from 24 SSPs, representing different organizational types and regions across the United States, discussed their experiences implementing clinical services. Their experiences, along with other research and expert guidance, are summarized in this fact sheet. This resource shares findings from the Strengthening Syringe Services Programs project and was made possible by U.S. Centers for Disease Control and Prevention (CDC) cooperative agreement NU52PS910232. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of CDC. The fact sheet can be found and downloaded here: Implementing Clinical Services within Syringe Services Programs