
This concept note proposes CREST — a subcutaneous implant designed to deliver emergency benzodiazepine medication during generalised tonic-clonic seizures without electronics or external triggers. The mechanism relies on seizure-induced lactic acidosis as a physiological trigger for pH-sensitive polymer erosion and controlled midazolam release. This document is an early-stage concept intended to establish date of priority and invite technical critique.
bioengineering, midazolam, implant, medical device, drug delivery, epilepsy, pH-sensitive polymer
bioengineering, midazolam, implant, medical device, drug delivery, epilepsy, pH-sensitive polymer
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 0 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
