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ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
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Claim

Mineral crisis as evolutionary driver: the Carnian Pluvial Episode, mammalian orotate-mediated magnesium transport, and lithium orotate as a contemporary footprint

descriptionPublicationkeyboard_double_arrow_right Preprint 01 May 2026 English Publisher:Zenodo
Authors: Hall, A. D.;

doi: 10.5281/zenodo.19952319 , 10.5281/zenodo.19952318

Mineral crisis as evolutionary driver: the Carnian Pluvial Episode, mammalian orotate-mediated magnesium transport, and lithium orotate as a contemporary footprint

Abstract

We propose that a coordinated transport infrastructure present in modern mammals — comprising the SLC2A9 (GLUT9) facilitative transporter and the SLC22A12 (URAT1) organic anion exchanger — arose during the Carnian Pluvial Episode (~234-232 Ma) under selection for maternal magnesium delivery to offspring, and that the same infrastructure accounts for the distinctive pharmacokinetics of lithium orotate observed in modern mammals.

Keywords

GLUT9, lithium orotate, URAT1, CPE, Magnesium Deficiency, Mammal

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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