In metropolitan areas, high-rise structures are built with various irregularities in their design and loading conditions. These irregular structures can experience sudden and significant effects when subjected to different types of loads, which is why additional considerations are necessary to prevent undesirable outcomes. Past earthquakes have demonstrated the adverse consequences that can occur in such structures. To mitigate these adverse effects, nonlinear analysis techniques like the P-Δ effect have been investigated in this current study. The P-Δ effect refers to the additional actions exerted on a structure due to its deformation resulting from applied stresses. In the study, the axially loaded columns of G+18 story structures were analysed using ETABS software under nonlinear dynamic time history conditions, taking into account the influence of the P-Δ effect. The displacement and drift response analysis revealed that these values tend to be higher as the height of the structure height increases. This finding underscores the importance of considering the P-Δ effect in structural analysis. By comparing the results with and without the consideration of the P-Δ effect, it was observed that there was an approximately eight percent variation in the outcomes. This indicates that neglecting the P-Δ effect could lead to significant discrepancies in the analysis results, further highlighting its significance in accurately predicting structural behaviour.