The CT:IQ Site Guide to Flexible Trial Participation gives clinical trial site staff tools to assess what flexible trial delivery methods can be offered for their clinical trials, and how to discuss these options with trial participants to decide which of the options available will work best for them. This document is part of the CT:IQ Flexible Trial Delivery project. This project is about giving participants options rather than dictating a set mode of clinical trial participation, either in-person or through technology.