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FAIR-MIND Application Profile v3: Ontology Mapping for Integrating Depression Clinical Data with ECG-derived HRV Biomarkers

Authors: Choi, Inkyung;

FAIR-MIND Application Profile v3: Ontology Mapping for Integrating Depression Clinical Data with ECG-derived HRV Biomarkers

Abstract

OWL/Turtle serialisation of the FAIR-MIND Application Profile (AP v3), mapping 39 variables across four layers — Clinical (SNOMED CT), Biomarkers (EFO, NCIT, FAIR-MIND), Provenance (PROV-O, LOINC), and Medications (CHEBI, MeSH) — to formal ontology terms. Includes SHACL validation shapes (7 shapes, 0 violations) and SPARQL competency question validation (10/10 CQs passing). Validated on MIMIC-IV-ECG subset (~290,000 ECG records).

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