Innovations in science and technology play a central role in driving global socioeconomic development, yet their spatial distribution and regional impacts are uneven. This study explores the interactions between technological innovations and geographic space, examining how they shape regional growth, knowledge networks, and environmental outcomes. Using a combination of spatial analysis, case studies, and a review of innovation system literature, the research identifies patterns of technological clustering, mechanisms of knowledge diffusion, and factors influencing regional disparities. The results indicate that proximity to research hubs, robust digital infrastructure, and supportive institutional frameworks significantly affect innovation performance. Strategic regional planning can, therefore, reduce spatial inequalities and enhance the effectiveness of technological interventions. This work provides a geographic framework for understanding how science and technology innovations are embedded in place and space.