The present study was undertaken to study and compare the visually impaired and Orthopedically challenged students on various dimensions of mental health and academic achievement. 100 visually impaired and 100 orthopedically challenged students were selected for the present investigation. The investigators used Alpana Sen Gupta`s Mental Health Battery for the collection of data. The collected data was analyzed by some statistical techniques. Some interesting conclusion has been drawn from the present study. The visually impaired and orthopedically challenged students showed somewhat similar mental health, but a significant mean difference was found between two groups of students on their academic achievement.