This study examines the operational efficiency outcomes of CRM–cloud integration among 214 service sector firms in Tashkent, Uzbekistan (2021–2023). Five key performance indicators (KPIs) showed statistically significant improvement following integration: customer response time fell 68.6%, administrative workload declined 72.8%, customer retention rose 15.8 percentage points, revenue per customer grew 21.4%, and data entry error rates dropped 93.7%. OLS regression identifies integration depth as the dominant predictor of efficiency gain (β = 0.72, R² = 0.61, p < 0.001), with staff training intensity as a significant positive moderator. The study advances an evidence-based integration framework and actionable recommendations for service enterprise managers and digital economy policymakers in Uzbekistan.