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Saikosaponin-d (Bupleurum falcatum) for GSS Enzyme Stabilization

descriptionPublicationkeyboard_double_arrow_right Preprint Under curationPublisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19833787

Saikosaponin-d (Bupleurum falcatum) for GSS Enzyme Stabilization

Abstract

Saikosaponin-d acts as a pharmacological chaperone, stabilizing partially functional GSS mutants through direct protein binding and prevention of aggregation. Additionally activates autophagy via mTOR inhibition and TFEB nuclear translocation, enhancing clearance of misfolded GSS proteins and damaged organelles.

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