Withanoside VI, a lesser-known withanolide from Withania somnifera, directly activates acetyl-CoA acetyltransferase and 3-hydroxy-3-methylglutaryl-CoA synthase, bypassing the defective lyase enzyme. Indian research shows this compound enhances alternative ketogenic pathways while reducing neuroinflammation through NLRP3 inflammasome inhibition and microglial M2 polarization.