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ZENODO
Preprint . 2026
License: CC 0
Data sources: ZENODO
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
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Withanoside VI from Ashwagandha for Ketogenesis Enhancement

descriptionPublicationkeyboard_double_arrow_right Preprint 28 Apr 2026Publisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19833739 , 10.5281/zenodo.19833740

Withanoside VI from Ashwagandha for Ketogenesis Enhancement

Abstract

Withanoside VI, a lesser-known withanolide from Withania somnifera, directly activates acetyl-CoA acetyltransferase and 3-hydroxy-3-methylglutaryl-CoA synthase, bypassing the defective lyase enzyme. Indian research shows this compound enhances alternative ketogenic pathways while reducing neuroinflammation through NLRP3 inflammasome inhibition and microglial M2 polarization.

IPFS: QmaBDkRpw5ZeWjBgUU3Ngz6vn74o45LL1iA3umncXPuhW3. TX: 0x17dbbb72abdd6a10f72d436ff5a431f1ed0b76cc7437510730d0fa178acf91fc. CC0.

Keywords

3-hydroxy-3-methylglutaric aciduria, drug repurposing, MedicOath, traditional_medicine

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average