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PI3K/AKT/mTOR Triple Inhibition for PIK3CA-Mutant Extramammary Paget Disease

descriptionPublicationkeyboard_double_arrow_right Preprint Under curationPublisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19833697

PI3K/AKT/mTOR Triple Inhibition for PIK3CA-Mutant Extramammary Paget Disease

Abstract

Open Targets identifies PIK3CA (0.28), AKT1 (0.29), and MTOR (0.28) all with similar scores. KEGG shows AKT1 participates in multiple resistance pathways (hsa01521, hsa01522, hsa01524). Triple pathway inhibition targets the entire signaling cascade preventing resistance mechanisms.

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