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ZENODO
Preprint . 2026
License: CC 0
Data sources: ZENODO
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
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Ginkgo biloba Terpenoids for X-Chromosome Gene Dosage Compensation

descriptionPublicationkeyboard_double_arrow_right Preprint 28 Apr 2026Publisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19833545 , 10.5281/zenodo.19833544

Ginkgo biloba Terpenoids for X-Chromosome Gene Dosage Compensation

Abstract

Ginkgolides A and B modulate HDAC2/3 activity and enhance chromatin remodeling complexes involved in X-inactivation mechanisms. These terpenoids upregulate XIST expression and promote heterochromatin formation, potentially compensating for the failed X-inactivation in pentasomy X by pharmacologically enhancing silencing of supernumerary X chromosomes.

IPFS: QmaUwfMV4TAytWKFiEoJ9NDKtFoKSMvKA9gymWa7PyxjZf. TX: 0xeb9ad7439b3f63a32c5d45395dcaee8ca66ce486ade94d7cf47fe1a40c195fdd. CC0.

Keywords

drug repurposing, MedicOath, Pentasomy X syndrome, traditional_medicine

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average