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Curcuma longa Ar-Turmerone for Blood-Brain Barrier 2-HG Transport

descriptionPublicationkeyboard_double_arrow_right Preprint Under curationPublisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19833445

Curcuma longa Ar-Turmerone for Blood-Brain Barrier 2-HG Transport

Abstract

Ar-turmerone from turmeric essential oil modulates organic anion transporters OAT1 and OAT3 to enhance 2-hydroxyglutarate efflux from brain tissue while simultaneously inhibiting monocarboxylate transporter-mediated re-uptake. This creates a favorable gradient for 2-HG clearance from the CNS compartment.

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