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ZENODO
Preprint . 2026
License: CC 0
Data sources: ZENODO
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
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Quinacrine Repurposing for PrPSc Aggregation Inhibition

descriptionPublicationkeyboard_double_arrow_right Preprint 28 Apr 2026Publisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19832955 , 10.5281/zenodo.19832956

Quinacrine Repurposing for PrPSc Aggregation Inhibition

Abstract

Quinacrine binds directly to the cellular prion protein (PrPC) and inhibits its conversion to the pathogenic scrapie form (PrPSc) by stabilizing the native α-helical structure. The drug interferes with the β-sheet formation characteristic of misfolded prions and may enhance clearance of existing aggregates through autophagy activation.

IPFS: QmbC2ypU6hBQjjQueWEyJYJDLrxE1MnYcgRYhRDHEapQAp. TX: 0x5774b4dead605eec685be171e31c52100e068d604f80fbd4b70370abdd607359. CC0.

Keywords

Creutzfeldt-Jakob Disease, drug repurposing, MedicOath, repurposing

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green