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ZENODO
Preprint . 2026
License: CC 0
Data sources: ZENODO
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
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Claim

PARP1 Inhibition with Olaparib for Metabolic Reprogramming in GSS Deficiency

descriptionPublicationkeyboard_double_arrow_right Preprint 28 Apr 2026Publisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19832897 , 10.5281/zenodo.19832898

PARP1 Inhibition with Olaparib for Metabolic Reprogramming in GSS Deficiency

Abstract

PARP1 inhibition reduces NAD+ consumption, enhancing SIRT1-mediated activation of antioxidant gene programs. Simultaneously activates AMPK-mediated metabolic reprogramming toward pentose phosphate pathway, increasing NADPH production for alternative antioxidant systems (thioredoxin, peroxiredoxin) to compensate for glutathione deficiency.

IPFS: QmZMFn2toWJvz5DuD15Ef89wEqpVZbvK1QzJQ2LWeVEmjb. TX: 0xe84c8701597a8e94663fc23530faede06302ffa0ef425b462edbe9f06628a885. CC0.

Keywords

drug repurposing, Glutathione synthetase deficiency, MedicOath, repurposing

  • BIP!
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average