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ZENODO
Preprint . 2026
License: CC 0
Data sources: ZENODO
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
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Claim

Ginkgolide B from Traditional Chinese Medicine for Hereditary Hearing Loss via Platelet-Activating Factor Receptor Modulation

descriptionPublicationkeyboard_double_arrow_right Preprint 28 Apr 2026Publisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19832849 , 10.5281/zenodo.19832850

Ginkgolide B from Traditional Chinese Medicine for Hereditary Hearing Loss via Platelet-Activating Factor Receptor Modulation

Abstract

Ginkgolide B, a diterpene lactone from Ginkgo biloba, acts as a selective antagonist of platelet-activating factor receptor (PAFR) and inhibits inflammatory cascades in the inner ear. The compound blocks PAFR-mediated activation of NF-κB and reduces production of inflammatory mediators like TNF-α and IL-1β that damage cochlear hair cells. Additionally, ginkgolide B enhances microcirculation in the stria vascularis through modulation of endothelial nitric oxide synthase.

IPFS: QmSYL8GbqQX25hLpwTrtSKe4MfoVbKczYkTzNcs6qGpM7W. TX: 0x9ade2f5a19f78a9e16fa3260266e7ec883c9105fee45579f351cbaf43afe9b42. CC0.

Keywords

drug repurposing, Rare deafness, MedicOath, traditional_medicine

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average