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ZENODO
Preprint . 2026
License: CC 0
Data sources: ZENODO
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC 0
Data sources: Datacite
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Claim

Astragalus membranaceus Saponins for ATP1A1 Na+/K+-ATPase Enhancement

descriptionPublicationkeyboard_double_arrow_right Preprint 28 Apr 2026Publisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19832813 , 10.5281/zenodo.19832814

Astragalus membranaceus Saponins for ATP1A1 Na+/K+-ATPase Enhancement

Abstract

Astragaloside IV and cycloastragenol from Astragalus specifically upregulate ATP1A1 α-subunit expression via Nrf2-mediated transcription, enhancing basolateral Na+/K+-ATPase activity. This improves electrochemical gradient for apical H+ secretion while astragalus polysaccharides reduce inflammatory cytokine-mediated downregulation of acid-base transporters.

IPFS: QmQVFA9RgPeUKgtYvZhfGHsDkZw3Ujrya4DcZ2ASiMz7KJ. TX: 0x07f186993009c7f3158086f5b8443fca85cdccf40bd353ad55ea2523903800d1. CC0.

Keywords

drug repurposing, MedicOath, Distal renal tubular acidosis, traditional_medicine

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average