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Azithromycin Combination with Rifampicin for Enhanced T. pallidum pertenue Clearance

descriptionPublicationkeyboard_double_arrow_right Preprint Under curationPublisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19832787

Azithromycin Combination with Rifampicin for Enhanced T. pallidum pertenue Clearance

Abstract

Azithromycin targets the 23S rRNA subunit of T. pallidum pertenue ribosomes, while rifampicin inhibits bacterial RNA polymerase β-subunit (rpoB). The combination provides synergistic bactericidal activity against spirochetes and reduces selection pressure for macrolide resistance mutations in the 23S rRNA gene.

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