Curcuma longa Curcuminoids for Anti-inflammatory Modulation

Curcumin and demethoxycurcumin inhibit NLRP3 inflammasome activation and reduce IL-1β production through direct binding to NLRP3 protein and suppression of NF-κB signaling. This addresses the hyperinflammatory phenotype in mevalonic aciduria by targeting the downstream inflammatory cascade triggered by mevalonate kinase deficiency.

IPFS: QmSWQ3K6wPsiN9QXF6NePT7VYMCQt4U9CBdVLGdiuyurZB. TX: 0x47b1b3be8d3c29f1d4b7b4ccaa5b8826e02e7169ba8277e314b803fe9a647d6d. CC0.

Keywords

drug repurposing, MedicOath, traditional_medicine, Mevalonic aciduria

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average

Found an issue? Give us feedback

0

Average