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Potassium Channel Network Modulation Targeting KCNA/KCNC/KCNV Clusters

descriptionPublicationkeyboard_double_arrow_right Preprint Under curationPublisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19832483

Potassium Channel Network Modulation Targeting KCNA/KCNC/KCNV Clusters

Abstract

Open Targets identifies a cluster of potassium channels (KCNA1,3,4,5,6,10; KCNC4; KCNV2) all scoring 0.56-0.59. Simultaneous modulation of this K+ channel network using CHEMBL5722941 (pChEMBL: 9.74 for KCNS3/KCNH5) could restore muscle membrane stability and reduce fatigability by compensating for impaired cholinergic signaling.

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