Inappropriate disposal of hospital tablet wrappers, comprising aluminum plastic laminate and synthetic polymers, is an environmental risk. This paper presents a case study on microbial degradation as a sustainable solution, involving bacteria Pseudomonas putida and fungi Aspergillus niger. Pseudomonas putida exhibited dye degradation after 31 days, while Aspergillus niger facilitated the degradation of the polymer by day 49. Adaptation, degradation efficiency, and enzyme activities were considered, demonstrating the ability of soil microorganisms to degrade the tablet wrappers effectively.