Tribal populations in India experience disproportionately high infant mortality rates due to a combination of socioeconomic disadvantages, limited access to healthcare, and traditional practices. Understanding the specific determinants of infant mortality in these communities is essential for developing targeted interventions. India has made significant strides in reducing both infant mortality (40/1000 live births) and under-five mortality (52/1000 live births) but has been unable to achieve the Millennium Development Goal (MDG) by 2015. So, this study aimed to assess the causes of death in infants admitted to a tertiary care hospital in the tribal region. A Cross-Sectional study is conducted at tertiary care Hospital, focusing on studies that analyse infant mortality in tribal regions of India. The data of infant’s death taken from MRD section during period Sept 24 to Nov 24. Data entered and analysed by epi-info Software version 7.2.6.0. Among 112 infants’ death, 62(55.36%) are male and 50(44.64%) are female. Death was found more in rural area 96(85.71%) compared to urban area 16(14.29%). This study clearly show that higher (53.57%) death reported in Respiratory Distress which include Birth Asphyxia, Respiratory Distress Syndrome, Cardiac Respiratory Arrest, Meconium Aspiration Syndrome. And Congenital 18.75%, Infection 16.96%, malnutrition 1.79%, Necrotising enterocolitis 7.14%, Pneumonia 1.79% are reported. Significant association was found between Age group and low birth weight (p = 0.001). Deaths in neonates (first 28 days) are more common in children’s born with low birth weight. So, to reduce mortality more care is needed in infants with low birth weight.