Rapid image acquisition is essential in modern wet laboratory research, particularly in fields such as microbiology, pathology, and molecular diagnostics. Conventional microscopy often requires expensive imaging systems, limiting accessibility in resource-constrained settings. The integration of smartphone technology with microscopes through mobile holders presents a cost-effective alternative. This review explores the design, functionality, and applications of microscope mobile holders, emphasizing their role in enhancing research efficiency, documentation, and reproducibility. The paper also evaluates their advantages, limitations, and future potential in laboratory innovation.