Myocardial infarction (MI) represents one of the most common and life-threatening cardiovascular diseases worldwide. It is characterized by ischemic necrosis of the heart muscle due to prolonged obstruction of coronary blood flow. This paper provides a comprehensive overview of the pathological anatomy of myocardial infarction, including its etiology, morphological changes, histopathological features, and clinical implications. The study synthesizes findings from classical pathology, modern histology, and clinical research to highlight the importance of understanding myocardial infarction in both diagnostic and therapeutic contexts.