The study aims to elucidate the nature of the psychopathic personality within the scope of modern psychology and the methodologies for interacting with as presented in the prophetic biography. Utilizing descriptive-analytical, the study concludes that this personality was embodied by individuals during the Prophet's era in Mecca and Medina. The prophetic guidance in dealing with this personality employed diverse methods characterized by adaptability according to the situation and context and varying with time and place.