This paper develops a systematic extension of Meta-Operational Mathematics to the realm of operator algebras, encompassing both commutative and noncommutative settings. We elevate operations on C*-algebras and von Neumann algebras to the status of independent mathematical objects, and study meta-operations---composition, involution, exponentiation, logarithm, differentiation, integration, variation, infinite sums, and infinite compositions---acting upon them. An axiomatic system of ten axioms is established, incorporating the essential structural features of operator algebras: the involution, positivity, modular structure, and spectral theory. The category of meta-operations on operator algebras is shown to carry an endomorphism operad structure compatible with the involution, which is further endowed with a Hopf operad structure featuring a noncommutative correction term $\Gamma(L)$ absent in the commutative case. A concrete Hopf algebra morphism from the unary meta-operations to the Connes--Kreimer renormalization Hopf algebra is constructed in the operator-algebraic setting, thereby embedding the renormalization group flow of quantum field theory formulated via operator algebras into the meta-operational framework. Bornological convergence is introduced to handle infinite meta-operations on operator algebras, and is applied to the modular theory of Tomita--Takesaki and to spectral triples in noncommutative geometry. The path integral is reinterpreted as a trace on the operad over operator algebras, connecting to topological quantum field theory and the local index formula of Connes--Moscovici. Completely positive maps and quantum channels are identified as a distinguished class of meta-operations, and their Kraus decomposition and Gorini--Kossakowski--Sudarshan--Lindblad generators are expressed in meta-operational language. Operator-valued special functions (Gamma, Zeta, Theta, hypergeometric) are shown to belong to the meta-operational universe over operator algebras, and their fundamental identities become equations of meta-operations. The K-theory and KK-theory of operator algebras are reformulated as invariants of meta-operations, with the index map interpreted as a trace on the operad. All open problems from the original research program are reformulated as precise theorems with complete proofs. This work provides a unified language connecting operator algebra theory, noncommutative geometry, quantum information theory, and perturbative quantum field theory under a single coherent meta-operational framework.