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This study was conducted to evaluate the inhibitory activity of Sandoricum koetjape Merr. leaf extract to blood type O fibrin formation, where warfarin (positive), negative control and different extract concentrations (50%, 75% and 100%) were compared. The computed F-value for the treatment was 238 with degrees of freedom 2.7. For replication, the computed F-value obtained was 3 with degrees of freedom 2.7. The former F-value was significant at 0.5 and 0.1 level of probability and the latter, was not significant. Results showed that 100% concentration has the highest time of coagulation but replication was almost the same.