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PentaPen: Combining Penalized Models to Identify Important SNPs on Whole-genome Arabidopsis thaliana Data

Authors: Nikita Kohli; Jabed H. Tomal; Wenjun Lin; Yan Yan;

PentaPen: Combining Penalized Models to Identify Important SNPs on Whole-genome Arabidopsis thaliana Data

Abstract

In the rapidly advancing field of genomics, the identification of Single Nucleotide Polymorphisms (SNPs) plays a crucial role in understanding complex phenotypic traits. This study introduces "PentaPen", an innovative computational workflow which combines the strengths of five penalized models to achieve improved accuracy in SNP detection. We compare the performance of PentaPen with existing models, highlighting its advantages in solving problems arising from when the number of predictors exceeds the number of samples. Beyond model comparison, we provide insights into PentaPen's effectiveness in utilizing all SNPs as input, streamlines data pre-processing, and leverages parallel computation, enabling the workflow a considerable stride in SNP detection. Furthermore, a thorough evaluation and comparison of computational complexities signifies competitive edge of the workflow over individual penalized models. As future research directions, we propose applications of PentaPen to plant-specific characteristics and suggest further explorations to assess the robustness of its findings. In summary, this manuscript presents the genomics community with a tool that combines computational efficiency with high-precision SNP detection, making a strong contribution to the field of genomic research.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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