Within the context of the European green and digital transition and the growing attention to the security of supply of critical raw materials, there is an increasing need for analytical tools capable of supporting the development and assessment of emerging technologies from the earliest stages of their life cycle. In this framework, Techno-Economic Assessment (TEA) and Energy Efficiency Assessment (EEA) represent key approaches for coherently analyzing feasibility, potential performance, and the main trade-offs associated with new industrial processes, particularly in contexts characterized by low levels of technological maturity.In light of these considerations, this report focuses on the analysis of the methodological structure of TEA and EEA evaluations and on the definition of the relevant indicators applicable within the NEO-CYCLE project. Quantitative assessments will follow throughout the upcoming project phases, when greater availability of data and a higher level of technological maturity will be achieved.