The liver (hepar) is the largest parenchymal gland in the human body and is central to the metabolic regulation system. Due to the variety of functions performed, the liver participates in maintaining homeostasis, providing detoxification, synthetic processes, energy balance and immunological protection of the body. The relevance of studying the anatomical and physiological features of the liver is due to the high prevalence of hepatobiliary diseases and the importance of this organ in clinical practice. The purpose of this work is a comprehensive consideration of the anatomical structure and physiological properties of the human liver.