Aim: The present review aims to comprehensively summarize the phytochemical constituents, traditional uses, and pharmacological activities of Sapindus mukorossi, with emphasis on its potential as a natural therapeutic agent. Background: Sapindus mukorossi Gaertn., commonly known as soapnut or Reetha, is a medicinally important plant widely used in traditional systems such as Ayurveda. It is known for its diverse phytochemical composition, particularly rich in triterpenoid saponins, flavonoids, tannins, and glycosides, which contribute to its various therapeutic properties. Body: Extensive literature indicates that Sapindus mukorossi possesses a wide range of pharmacological activities, including anti-inflammatory, antimicrobial, antioxidant, wound healing, antifungal, antibacterial, cytotoxic, antiulcer, insecticidal, and antidiabetic effects. These activities are primarily attributed to its bioactive compounds, which act through mechanisms such as inhibition of inflammatory mediators, free radical scavenging, and disruption of microbial cell membranes. Traditionally, the plant has been used in the treatment of skin disorders, respiratory conditions, and as a natural cleansing agent due to its surfactant properties. Among different plant parts, the fruit pericarp is considered the most pharmacologically active. Conclusion: In conclusion, Sapindus mukorossi demonstrates significant therapeutic potential supported by both traditional knowledge and scientific evidence. However, further studies focusing on standardization, safety evaluation, and clinical validation are necessary to fully establish its role in modern medicine and facilitate its development into effective plant-based formulations.