Occupational health hazards remain a significant concern among healthcare workers due to their continuous exposure to biological, chemical, physical, ergonomic, and psychosocial risks. This study assesses the level of occupational hazards and the preventive practices adopted by healthcare workers in a Port Trust Authority Hospital using a descriptive research design with a sample of 120 respondents selected through purposive sampling. Data were collected through a structured questionnaire and analyzed using statistical tools such as percentage analysis, ANOVA, chi-square, and correlation tests. The findings reveal that healthcare workers are highly exposed to biological hazards, ergonomic issues, and workrelated stress; however, most respondents demonstrate good awareness and adherence to preventive practices, including the use of personal protective equipment (PPE), proper waste management, and participation in safety training programs. Furthermore, statistical analysis indicates significant associations between demographic factors and exposure to certain hazards. The study concludes that although preventive measures are widely practiced, continuous training, effective policy implementation, and regular monitoring are essential to further reduce occupational risks and enhance workplace safety.