Single-Cell Transcriptomic Identification of Novel Drug Repurposing Candidates for Heart Failure and Dilated Cardiomyopathy via Human Left Ventricular scRNA-seq (GSE161470)
Single-Cell Transcriptomic Identification of Novel Drug Repurposing Candidates for Heart Failure and Dilated Cardiomyopathy via Human Left Ventricular scRNA-seq (GSE161470)
Companion preprint to USPTO provisional patent application. Applies a 12-step computational pipeline to GSE161470 (Hu et al., human left ventricular scRNA-seq, 9,803 cells, DCM vs. normal). Reports cell-type-resolved differential expression, ChEMBL bioactivity screening (17,793 candidates), and PubChem novelty filtering identifying LESTAURTINIB, R-406, FORETINIB, CERDULATINIB, DASATINIB, and CHEMBL5653589 as novel repurposing candidates targeting the CSF1R/SYK macrophage inflammatory axis and cytoskeletal remodeling pathways. Authors: Glen Charles Ritschel (Ritschel Research, Tega Cay SC) and Claude (Anthropic, San Francisco CA). CC BY 4.0.
DASATINIB, SCN9A, drug repurposing, left ventricle, heart failure, CSF1R, computational pharmacology, NOVEL_ALL, dilated cardiomyopathy, LESTAURTINIB, scRNA-seq, SYK, CHEMBL5653589, single-cell transcriptomics, sodium channel
DASATINIB, SCN9A, drug repurposing, left ventricle, heart failure, CSF1R, computational pharmacology, NOVEL_ALL, dilated cardiomyopathy, LESTAURTINIB, scRNA-seq, SYK, CHEMBL5653589, single-cell transcriptomics, sodium channel
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