Road safety is a pressing issue worldwide, and road accidents involving trucks often have serious consequences. This article analyzes the role of intelligent transport systems (ITS) in improving the safety of freight transportation in Uzbekistan. The study is based on presidential decrees and orders, scientific literature, and the results of pilot projects in Tashkent. The results show that the main components of ITS—real-time monitoring, telematics sensors, artificial intelligence (AI), and V2X communication—are effective in improving safety and reducing congestion in freight transportation. In pilot projects, congestion was reduced by 15–20%, and the risk of road accidents was significantly reduced. The article develops strategic recommendations for expanding ITS in Uzbekistan, improving logistics efficiency, and optimizing the transport system. This study serves to harmonize the country's transport policy with advanced technologies and create a safe and efficient transport system.