There was an investigation done to observe whether smoking (cigarettes and/or arghile) would have an effect on the hemogram (or blood) and any correlation with blood type distribution. Out of 80 men in total, there were 40 smokers and 40 non-smokers in the control group. Data was collected about and analyzed to allow for comparisons between the groups in terms of age, years of smoking (duration), blood type, and assessed hematological parameters. The results indicated that there were more smokers aged 30-40 than young men aged 19 or younger in the control group. Men that smoked cigarettes predominantly had shorter smoking durations, while men that smoked arghile predominantly had longer smoking durations. There were no significant differences between smoking and blood type distribution (ABO and Rh). Some of the hematological parameters had statistically significant differences between smokers and non-smokers. Smokers had greater mean values for Hb, PCV, WBC counts, and ESR than non-smokers (P < 0.05). Meanwhile, there were no statistically significant differences noted in RBC counts and PLT. Generally, smoking appears to induce definite hematological changes in smokers (especially related to inflammation and oxygen transport) and may indirectly increase the risk of cardiovascular and inflammatory disease in smokers.