The existence, uniqueness and uniformly Lp estimates for solutions of a high-order abstract Navier–Stokes problem on half space are derived. The equation involves an abstract operator in a Banach space E and small parameters. Since the Banach space E is arbitrary and A is a possible linear operator, by choosing spaces E and operators A, the existence, uniqueness and Lp estimates of solutions for numerous classes of Navier–Stokes type problems are obtained. In application, the existence, uniqueness and uniformly Lp estimates for the solution of the Wentzell–Robin-type mixed problem for the Navier–Stokes equation and mixed problem for degenerate Navier–Stokes equations are established