Abstract Lichen simplex chronicus delineate’s a kind of chronic localized pruritus with a secondary dermatitis, as well as one of the maximum frequent kinds of chronic itch situations, determined to influence greater than 10% of the general population. Nevertheless, although it is prevalent in addition to possesses substantial load, there has been restricted work into the pathogenesis, along with causative factors of lichen simplex chronicus, that, as per history, enabled it to become a bothersome situation in reference to treatment. In recent decade, our insight of this situation, along with that of pruritus as well as the itch-scratch cycle, has escalated substantially, making an extensive escalation of avenues regarding therapy. Additionally, numerous attractive innovative therapies are generational in addition to trials. This mini-review details the definition, epidemiology, clinical properties, pathophysiology, along with present therapeutic opportunities for lichen simplex chronicus, with regards to emphasizing recent advancements in such arena.In milder cases use of emollients like N- palmitoylethanolamine,or with anaesthetic characteristics, for instance polidocanol, /Topical analgesic mixture of ketamine-amitriptyline-lidocaine (KAL) in a lipoderm basemight be of substantial help in contrast to need for systemic therapiesin greater robust cases KeyWords; Lichen simplex chronicus; itch-scratch cycle; innovative therapies.