Analytical Method Validation is crucial in pharmaceutical research and manufacturing process. Losartan Potassium and Enalapril Maleate Peaks were well resolved at retention times 9.604 and 2.604 min respectively for 1ml/min flow rate in isocratic mode at a run time of 15 min with Welchrom 250mm x 4.6mm, 5µm column & Ammonium acetate buffer: water: methanol (10:30:60) as mobile phase at 226nm. % Assay values were 99.52% and 99.15% for Losartan potassium and Enalapril maleate respectively. Linearity was produced in the range of 24-72 ppm for Losartan Potassium and 20-60 ppm for Enalapril Maleate with a correlation coefficient of 0.9993 & 0.9998 respectively. The new approach was verified using ICH requirements and found to be specific, sensitive, precise, reliable, and linear. The suggested approach may successfully estimate Losartan Potassium and Enalapril Maleate in marketed formulations.