Three Neotropical species of Phthinia Winnertz have been described to date. The genus is known from Chile and southern Argentina. Four new species are herein described for the genus in the region, two from Brazil—Phthinia theresae, sp.n., from the State of Espírito Santo, and Phithinia urubici, sp.n., from the State of Santa Catarina—and two from Chile—Phthinia freemani, sp.n., and Phthinia parafurcata, sp.n. Comments are made about the relationships between the Neotropical species. Some notes are added about P. furcata Freeman, P. flagellata Freeman, and P. fasciata Freeman, from Chile and southern Argentina. Attention is called for the fact that Phthinia has two species in Brazil disjunct from the other temperate species of the genus in South America, differently from most similar cases, that have a single known representative in Brazil.