TGS-BIO (Thermodynamic Geometry System for Biology) proposes a geometry-guided thermodynamic framework for manipulating local tissue environments to enhance wound healing. The central hypothesis is that controlled spatial and temporal distribution of thermal energy—delivered through engineered geometries and quasiperiodic pulse sequences—can modulate biological processes including microcirculation, inflammatory phase transitions, fibroblast activity, and oxygen transport. The system integrates physical principles derived from heat transfer, vascular optimization laws, and nonlinear temporal sequencing, including: Spatial confinement of thermal gradients using quasiperiodic structures Uniform energy distribution based on branching optimization principles Reduction of contact resistance through multiscale surface geometry Temporal modulation using quasiperiodic (Fibonacci-like) pulse schedules to prevent biological adaptation Unlike conventional approaches that rely primarily on biochemical interventions, this framework treats wound healing as a thermodynamic system governed by energy flow, entropy dynamics, and spatial gradients. This record establishes the conceptual and physical foundation of the TGS-BIO system. Detailed experimental protocols, validation criteria, and in-vitro testing frameworks are published separately as linked records. All claims are intended to be falsifiable and subject to experimental verification.