In IoT and wearable systems based on System on Chip (SoC), wired communication with off-chip devices is an essential part of the design. Developing this communication interface is not trivial and often application-dependent, which limits the re-usability of the code. This paper presents an effective method to simplify the development of communication interfaces and reduce their dependency on specific applications by providing useful design guidelines. In particular, our study targets complex computing platform such as heterogeneous SoCs, which integrate a general purpose processor and a Field Programmable Gate Array (FPGA) based programmable logic where hardware accelerators can be implemented. As a result of this work, we have developed a software library that can be reused for all devices utilizing i2c serial communication.