This review characterizes the role of low-dose singlet oxygen (1O2) as a non-pharmacological, hormetic stimulus. It provides the comprehensive biological and chemical framework for the generation method detailed in U.S. Patent 11,007,129 B2, bridging the gap between engineered molecular physics and cellular signaling. Key thematic areas include: Molecular Mechanisms: Analysis of the Nrf2-Keap1-SIRT6 axis and MAPK-mediated kinase rheostats. Cellular Adaptations: Induction of autophagic flux, including mitophagy and lipophagy. Technical Innovation: Comparison of traditional irradiative methods vs. non-irradiative catalytic generation for stable, sub-toxic output. Systemic Physiology: Integration of clinical observations regarding respiratory, sleep, and metabolic recalibration. This work serves as a theoretical foundation for understanding how controlled oxidative stimuli can trigger organism-level adaptive resilience.