This paper aims to present good practices in the field of social work and human mobility identified in a case study on trafficking of women in Andalusia, carried out by Red Acoge within the framework of the European Project Global-ANSWER between January and November 2024. The study comprehensively analyses public policies, legislation, social services, and social work practices applied in the support of women victims of sexual trafficking, with particular attention to migrant women. Human trafficking for the purpose of sexual exploitation constitutes one of the most serious human rights violations, disproportionately affecting migrant women. Andalusia, which concentrates almost a third of the victims of trafficking in Spain, is positioned as a key context for examining this phenomenon. Using a qualitative methodology, the study employed tools such as surveys, focus groups and semi-structured interviews with social professionals. This approach allowed for the collection of detailed information on the experiences, challenges and practices of organizations working directly with women survivors of trafficking. The social organizations play a crucial role in several areas: early detection of victims, specialized accompaniment, political advocacy with public administrations, networking with other entities and coordination with key agents such as the State Security Forces, the Public Prosecutor's Office and the Andalusian Women's Institute. Furthermore, the study highlights the relevance of these inter-institutional collaborations to effectively address trafficking in women and improve institutional responses. The analysis also highlights that, despite current efforts, many victims of trafficking remain invisible. According to the Cultura de datos en la trata de seres humanos report —Data Culture in Trafficking in Human Beings report— (Estrada Villaseñor et al., 2024), produced by the University Institute of Studies on Migration of the Pontifical University of Comillas, for every detected victim there are approximately 4.6 unidentified victims in Spain. This detection gap highlights the urgency of strengthening data collection systems and improving identification strategies. Among the most relevant conclusions, it is highlighted that effective cooperation between public administrations and third social action sector entities is essential to address the complex nature of human trafficking. It also emphasizes the need to strengthen the resources and capacities of social organizations, which play a central role in the care and protection of victims. The good practices or best practices identified not only offer a replicable model for other regions but also provide valuable recommendations for optimizing public policies and services aimed at combating trafficking in women and guaranteeing the rights of its victims.