Currently, ectoine is one of the most profitable products produced by microorganisms. Due to its high effectiveness as stabiliser of enzymes, DNA-protein complexes, and nucleic acids, ectoine has a value in the pharmaceutical industry of approximately 1,000 US$/kg. This osmolyte can be produced from the methane present in biogas but this technology still exhibits mass-transfer limitations. Taylor flow reactors represent a promising platform to conduct biogas bioconversion. A 10-L Taylor flow reactor fed with CH4-laden air (5%) was optimized for ectoine production for the first time. Methane conversion efficiencies of 85% with ectoine contents > 10% (w/w) were achieved, which represent the highest figures reached so far.